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“Driving chemical innovation in optical probes for research and clinical diagnostics”
The World's First Full Bilayer Spanning Lipophilic Dyes: Water Soluble Acoerela Dyes
Accurate, Fast and Easy to Use
>95%
Accuracy
Current dyes false positivity rate of over 70%
1
Hour
Current dyes can take >8 hours to get results
1
Step
Current dyes require multistep processing
Why choose Acoerela
Fluorogenic
Acoerela dyes are characterized by a high quantum yield (>25%). The significant increase in fluorescence is only observed when the dyes are bound to their target, in which there is change in the hydrophobicity of the environment surrounding the dyes. The stark difference in emission profiles between bound and unbound dyes underlie the “light on” mechanism.
Diverse color options
The current chromophore platform of Acoerela dyes allows us to derive up to 3 different colors
and we are expanding on the excitation/emission profiles of these dyes to enable more multiplexing possibilities in different applications.
Water soluble
Acoerela Dyes are highly water soluble and do not form micelles or nanoparticles when reconstituted in aqueous buffer, unlike that of the family of PKH26, DiR and DiD dyes which will give rise to false positives in flow cytometry analysis of exosomes.
More About Acoerela Dyes
In this one minute video, learn more about what Acoerela has to offer with our range of dyes. Our experts have made a highly soluble dye that can be easily incorporated into your research. Reach out today to see how we can work in tandem to take your research to the next level.
The World's First Full Bilayer Spanning Lipophilic Dyes
Water Soluble Acoerela Dyes
Many dyes are highly hydrophobic and often require reconstitution in an organic solvent such as DMSO or ethanol. Unfortunately, these solvents may induce artifact changes when present in biological samples because they are not as biocompatible as aqueous buffers. Moreover, some dyes (e.g., carbocyanine) have the tendency to form nanoaggregates when they are being serially diluted from their DMSO or ethanolic stocks. These dye nanoaggregates are potentially sources of false positive signals when analyzing small biological particles like exosomes.
Acoerela Company Introduction
Acoerela is a start-up from the National University of Singapore
(NUS). We, the founding team of Acoerela, started out as
academic researchers from a diversity of scientific background
ranging from materials chemistry, biophysics and life sciences
fields. The core expertise of the team lies in our unique chemistry
technology and we are committed to translate our technology
into innovative products that will serve the research community
at large, both from the academia and industry spaces.